ea0020p130 | Thyroid | ECE2009
Kim Doo-Man
, Kim Hyeon Kyu
, Yoo Soon Jib
Thyroxine-binding globulin (TBG), the major transport protein for thyroid hormone in circulation, is synthesized in the liver. Complete TBG deficiency was first reported in 1964, and in 1991 a single nucleotide deletion was found in the first base of the codon for amino acid 352 of the common-type TBG molecule. This mutation causes a frameshift in translation and premature termination. Most people with abnormal TBG concentrations are euthyroid. Cases of GravesÂ’ disease wi...